A large-scale distributed network for covert spatial attention - Further anatomical delineation based on stringent behavioural and cognitive controls
A large-scale distributed network for covert spatial attention - Further anatomical delineation based on stringent behavioural and cognitive controls
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DOI：
10.1093/brain/122.6.1093
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发表时间：
1999-06-01
期刊：
影响因子：
14.5
通讯作者：
Mesulam, MM
中科院分区：
文献类型：
--
作者：
Gitelman, DR;Nobre, AC;Mesulam, MM
研究人员使用功能性核磁共振成像（Functional MRI）检查了12名受试者在执行空间注意力任务时的大脑活动情况。与之前的类似实验相比，这项研究采用了更严格的行为和认知控制：(i)只有当受试者在磁铁中执行任务时表现出注意力转移的迹象时，他们才被纳入研究；（ii）实验任务和基线条件的设计是为了消除运动输出、视觉固定、眼球运动抑制、工作记忆和条件（不去）反应成分的贡献，在所有三个假设的皮层震中都可以看到激活，形成空间注意网络。外侧运动前皮层（额眼区）、后顶叶皮层和扣带皮层、基底神经节和丘脑皮层下被激活。尽管任务要求注意力同样向左和向右转移，但10名受试者中有8名显示右侧顶叶皮层的激活面积更大，这与右半球对空间注意力的专门化一致。其他显著激活的区域包括后颞枕皮质和前脑岛。颞枕区激活的区域被广泛定义为MT+（其中MT是颞叶中部区域），该区域包含与猕猴MT区域相当的人类区域，该颞枕区似乎构成了由空间注意任务激活的功能网络的主要组成部分。它的激活可能反映了注意力在视觉场景中的“推断”转移。
Functional MRI was used to examine cerebral activations in 12 subjects while they performed a spatial attention task. This study applied more stringent behavioural and cognitive controls than previously used for similar experiments: (i) subjects were included only if they showed evidence of attentional shifts while performing the task in the magnet; (ii) the experimental task and baseline condition were designed to eliminate the contributions of motor output, visual fixation, inhibition of eye movements, working memory and the conditional (no-go) component of responding, Activations were seen in all three hypothesized cortical epicentres forming a network for spatial attention: the lateral premotor cortex (frontal eye fields), the posterior parietal cortex and the cingulate cortex, Subcortical activations were seen in the basal ganglia and the thalamus, Although the task required attention to be equally shifted to the left and to the right, eight of 10 subjects showed a greater area of activation in the right parietal cortex, consistent with the specialization of the right hemisphere for spatial attention, Other areas of significant activation included the posterior temporo-occipital cortex and the anterior insula, The temporo-occipital activation was within a region broadly defined as MT+ (where MT is the middle temporal area) which contains the human equivalent of area MT in the macaque monkey, This temporo-occipital area appears to constitute a major component of the functional network activated by this spatial attention task, Its activation may reflect the 'inferred' shift of the attentional focus across the visual scene.