Ovine atadenovirus: a review of its biology, biosafety profile and application as a gene delivery vector
Ovine atadenovirus: a review of its biology, biosafety profile and application as a gene delivery vector
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DOI：
10.1046/j.0818-9641.2004.01223.x
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Both, GW
中科院分区：
文献类型：
--
作者：
Both, GW
卵巢腺病毒分离株OADV287是新近认识的Atadenovires属的原型。尽管研究不像人类毛ad虫那样很好，但是现在已经对这种病毒进行了大量的工作，并且对其有趣且独特的特性的理解开始出现。在本文中，回顾了该病毒的生物安全性。这些知识基于将病毒作为基因递送载体的剥削。总结和讨论了其作为疫苗载体的潜力及其在前列腺癌治疗中的应用。
The ovine adenovirus isolate OAdV287 is the prototype of the newly recognized genus of atadenoviruses. Although not as well studied as human mastadenoviruses, a substantial amount of work has now been carried out with this virus and an understanding of its interesting and unique properties is beginning to emerge. In this article the biology and biosafety profile of the virus is reviewed. This knowledge underpins the exploitation of the virus as a gene delivery vector. Its potential as a vaccine vector and its application to the treatment of prostate cancer is summarized and discussed.