Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
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仿生多功能混合水凝胶促进伤口愈合
DOI：
10.1002/adfm.201801386
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发表时间：
2018-08-15
影响因子：
19
通讯作者：
Zhao, Yuanjin
中科院分区：
文献类型：
--
作者：
Chen, Guopu;Yu, Yunru;Zhao, Yuanjin
受生物体协调的多重愈合机制的启发，提出了一种具有血管内皮生长因子（VEGF）包封的四臂苯并噻吩封端的聚乙二醇和十二烷基改性的壳聚糖杂化水凝胶，用于有效和通用的伤口愈合。该杂化水凝胶由可逆席夫碱形成，具有自修复能力。由于十二烷基尾可以插入并锚定在细胞膜的脂质双层上，因此杂化水凝胶具有突出的组织粘附、血细胞凝固和止血、抗感染和细胞募集功能。此外，通过加载混合水凝胶并从混合水凝胶可控地释放VEGF，可以显著改善伤口床中的细胞增殖和组织重塑过程。基于多功能杂化水凝胶的体内研究，证明了由于水凝胶的突出粘附和止血特征，急性组织损伤如血管出血和肝出血可以立即修复。此外，感染性全层皮肤缺损模型的慢性伤口愈合过程也可以通过促进血管生成、胶原沉积、巨噬细胞极化和肉芽组织形成而显著增强。因此，这种多功能杂化水凝胶具有潜在的临床应用价值。
Inspired by the coordinated multiple healing mechanism of the organism, a four-armed benzaldehyde-terminated polyethylene glycol and dodecyl-modified chitosan hybrid hydrogel with vascular endothelial growth factor (VEGF) encapsulation are presented for efficient and versatile wound healing. The hybrid hydrogel is formed through the reversible Schiff base and possesses self-healing capability. As the dodecyl tails can insert themselves into and be anchored onto the lipid bilayer of the cell membrane, the hybrid hydrogel has outstanding tissue adhesion, blood cell coagulation and hemostasis, anti-infection, and cell recruitment functions. Moreover, by loading in and controllably releasing VEGF from the hybrid hydrogel, the processes of cell proliferation and tissue remodeling in the wound bed can be significantly improved. Based on an in vivo study of the multifunctional hybrid hydrogel, it is demonstrated that acute tissue injuries such as vessel bleeding and liver bleeding can be repaired immediately because of the outstanding adhesion and hemostasis features of the hydrogel. Moreover, the chronic wound-healing process of an infectious full-thickness skin defect model can also be significantly enhanced by promoting angiogenesis, collagen deposition, macrophage polarization, and granulation tissue formation. Thus, this multifunctional hybrid hydrogel is potentially valuable for clinical applications.