Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment.
Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment.
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DOI：
10.1016/j.stemcr.2016.11.002
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发表时间：
2016-12-13
影响因子：
5.9
通讯作者：
Suzuki, Atsushi
中科院分区：
文献类型：
--
作者：
Sekiya, Sayaka;Miura, Shizuka;Matsuda-Ito, Kanae;Suzuki, Atsushi
肝祖细胞（HPC）出现在人类和啮齿动物肝脏中的几种类型的慢性损伤中，这些损伤通常发展为肝纤维化、肝硬化和原发性肝癌。然而，HPC对此类肝病的发病机制和进展的贡献仍然存在争议。HPC通常被定义为可以分化为肝细胞和胆管细胞的细胞。然而，在这项研究中，我们发现从慢性损伤的肝脏中分离的HPC也可以产生肌成纤维细胞作为第三种后代。虽然从HPC分化的肌成纤维细胞在培养中并不显著，但在肿瘤发展期间，HPC可以通过产生丰富的肌成纤维细胞来促进肿瘤微环境的形成，所述肌成纤维细胞可能形成肿瘤生长和存活的生态位。因此，HPC可以被重新定义为具有分化为肌成纤维细胞的潜力的细胞，其在肿瘤形成期间被特异性激活。从慢性损伤的肝脏中分离的HPCs可以产生肌成纤维细胞HPCs在培养中产生肌成纤维细胞的频率很低HPCs可以在肿瘤发展过程中产生大量的肌成纤维细胞HPCs本身可以促进肿瘤微环境的形成在这篇文章中，Suzuki和同事发现肝祖细胞（HPCs）具有向肝细胞、胆管细胞、和肌成纤维细胞。尽管在培养物中从HPC产生肌成纤维细胞的频率较低，但HPC可在肿瘤发展期间产生许多肌成纤维细胞，并有助于肿瘤微环境的形成。
Hepatic progenitor cells (HPCs) appear in response to several types of chronic injury in the human and rodent liver that often develop into liver fibrosis, cirrhosis, and primary liver cancers. However, the contribution of HPCs to the pathogenesis and progression of such liver diseases remains controversial. HPCs are generally defined as cells that can differentiate into hepatocytes and cholangiocytes. In this study, however, we found that HPCs isolated from the chronically injured liver can also give rise to myofibroblasts as a third type of descendant. While myofibroblast differentiation from HPCs is not significant in culture, during tumor development, HPCs can contribute to the formation of the tumor microenvironment by producing abundant myofibroblasts that might form a niche for tumor growth and survival. Thus, HPCs can be redefined as cells with a potential for differentiation into myofibroblasts that is specifically activated during tumor formation. HPCs isolated from the chronically injured liver can give rise to myofibroblasts The frequency of myofibroblast production from HPCs is low in culture HPCs can give rise to a number of myofibroblasts during tumor development HPCs themselves can contribute to the formation of the tumor microenvironment In this article, Suzuki and colleagues found that hepatic progenitor cells (HPCs) have a potential for trilineage differentiation into hepatocytes, cholangiocytes, and myofibroblasts. Although the frequency of myofibroblast production from HPCs is low in culture, HPCs can give rise to a number of myofibroblasts during tumor development and contribute to the formation of the tumor microenvironment.
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