Cell size control - New evidence for a general mechanism
Cell size control - New evidence for a general mechanism
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DOI：
10.4161/cc.4.3.1523
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发表时间：
2005-03-01
期刊：
影响因子：
4.3
通讯作者：
Mullner, EW
中科院分区：
文献类型：
--
作者：
Grebien, F;Dolznig, H;Mullner, EW
连续增殖的细胞必须在每个周期中精确地将其大小加倍，以保持恒定的体积。这一事实一次又一次地提出了真核细胞中是否存在一种活跃的细胞大小控制机制的问题，这种机制可以防止细胞在质量不足时延迟或过早分裂。我们通过在动物细胞中总结几个长期存在的实验来解决这个开放性问题，这些实验已经确定了酵母中的这种机制。
Continuously proliferating cells have to precisely double their size during each cycle to maintain constant volumes. Time and again, this fact raised questions on the existence of an active cell size control mechanism in eukaryotic cells, which would prevent delayed or premature cell division at inadequate mass. We addressed this open issue by recapitulating in animal cells several long-standing experiments which had identified such a mechanism in yeast.