ROS-dependent signal transduction.
ROS-dependent signal transduction.
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DOI：
10.1016/j.ceb.2014.09.010
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发表时间：
2015-04
影响因子：
7.5
通讯作者：
Chandel NS
中科院分区：
文献类型：
--
作者：
Reczek CR;Chandel NS
活性氧物种(ROS)不再仅仅被视为线粒体呼吸的有毒副产物，而是现在被认为在调节无数细胞信号通路中的作用。过氧化氢是ROS的一种，是一种信号分子，通过硫醇氧化提供靶标特异性。尽管氧化还原依赖的信号参与了许多细胞过程，但面对高活性和丰富的抗氧化剂，ROS信号传递到靶蛋白的机制尚不完全清楚。在这篇关于氧化还原信号生物学的综述中，我们讨论了过氧化氢依赖的信号转导的可能机制。
Reactive oxygen species (ROS) are no longer viewed as just a toxic by-product of mitochondrial respiration, but are now appreciated for their role in regulating a myriad of cellular signaling pathways. H2O2, a type of ROS, is a signaling molecule that confers target specificity through thiol oxidation. Although redox-dependent signaling has been implicated in numerous cellular processes, the mechanism by which the ROS signal is transmitted to its target protein in the face of highly reactive and abundant antioxidants is not fully understood. In this review of redox-signaling biology, we discuss the possible mechanisms for H2O2-dependent signal transduction.