Current strategies for sustaining drug release from electrospun nanofibers.
Current strategies for sustaining drug release from electrospun nanofibers.
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DOI：
10.1016/j.jconrel.2015.09.008
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发表时间：
2015-12-28
期刊：
影响因子：
--
通讯作者：
Woodrow KA
中科院分区：
文献类型：
--
作者：
Chou SF;Carson D;Woodrow KA
静电纺丝药物洗脱纤维正在成为一种新的剂型，用于多用途预防性传播感染，包括艾滋病毒和意外怀孕。我们实验室和其他人以前的工作显示了这个平台的多功能性，可以提供大剂量的物理化学不同的试剂。然而，由于内在的低效力或持续预防的需要，仍然存在开发用于高剂量所需的水溶性小分子药物的实用纤维制剂的未满足的需求。迄今为止，大多数缓释纤维仅限于以通常<1wt%的低载药量递送生物制剂或疏水性小分子，这对于大多数临床应用来说通常是不切实际的。对于亲水性小分子药物，它们的高水溶性和差的分配以及与不溶性聚合物的不相容性使得长期释放更具挑战性。在这里，我们研究了几种现有的策略，以持续释放的亲水性小分子药物，是高度负载在静电纺丝纤维。特别是，我们调查什么是已知的设计约束，实现多天释放从单轴和同轴静电纺丝制造的纤维。
Electrospun drug-eluting fibers are emerging as a novel dosage form for multipurpose prevention against sexually transmitted infections, including HIV, and unintended pregnancy. Previous work from our lab and others show the versatility of this platform to deliver large doses of physico-chemically diverse agents. However, there is still an unmet need to develop practical fiber formulations for water-soluble small molecule drugs needed at high dosing due to intrinsic low potency or desire for sustained prevention. To date, most sustained release fibers have been restricted to the delivery of biologics or hydrophobic small molecules at low drug loading of typically < 1 wt.%, which is often impractical for most clinical applications. For hydrophilic small molecule drugs, their high aqueous solubility and poor partitioning and incompatibility with insoluble polymers make long-term release even more challenging. Here we investigate several existing strategies to sustain release of hydrophilic small molecule drugs that are highly-loaded in electrospun fibers. In particular, we investigate what is known about the design constraints required to realize multi-day release from fibers fabricated from uniaxial and coaxial electrospinning.