Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application
Enhancement of corrosion resistance and biocompatibility of Mg-Nd-Zn-Zr alloy achieved with phosphate coating for vascular stent application
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磷酸盐涂层提高Mg-Nd-Zn-Zr合金的耐腐蚀性和生物相容性，用于血管支架
DOI：
10.1016/j.jmrt.2020.04.024
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发表时间：
2020-05-01
影响因子：
6.4
通讯作者：
Song, Chengli
中科院分区：
文献类型：
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作者：
Mao, Lin;Zhu, Hongwang;Song, Chengli
为了提高Mg-Nd-Zn-Zr（简称JDBM）合金的耐蚀性和生物学响应性，我们开发了一种简便的化学转化方法，在该合金表面制备了一种宽约1-5 μ m的层状结构Mg-3（PO 4）（2）涂层。磷化膜对JDBM合金的保护作用使其耐蚀性从0.337 ± 0.021 mm y（-1）提高到0.253 ± 0.047 mm y（-1），提高了约25%。体外细胞相容性试验的系统研究表明，磷酸盐涂层JDBM对人脐静脉内皮细胞（HUVECs）的活力、生长和增殖的负面影响很小，并且涂层通过支持更高的贴壁细胞密度和足够的细胞铺展而对HUVECs具有良好的亲和力。此外，体外血液相容性研究证实了磷酸盐涂层JDBM的溶血率降低和优异的抗血小板粘附性能。此外，这项研究还提出了我们最近的努力，以深入了解的机制，这是涉及抗血小板粘附在可生物降解的镁基板的表面。(C)2020作者（S）由爱思唯尔公司出版
We have developed a convenient chemical conversion method of preparing a Mg-3(PO4)(2) coating with a lamellar structure of about 1-5 mu m width on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to improve the corrosion resistance and biological response. The protective effect of the phosphate coating on JDBM alloy leads to an increase in corrosion resistance of about 25% from 0.337 +/- 0.021 to 0.253 +/- 0.047 mm y(-1). A systematic study on in vitro cytocompatibility test shows that the phosphate coated JDBM has minimal negative effect on human umbilical vein endothelial cells (HUVECs) viability, growth and proliferation, and the coating also presents a favorable affinity for HUVECs by supporting higher adherent cell density and sufficient cell spreading. In addition, the investigation of in vitro hemocompatibility confirms reduced hemolysis ratio and excellent anti -platelet adhesion property of the phosphate coated JDBM. Furthermore, this study also presents our more recent efforts to develop an in-depth understanding of the mechanism which is involving anti-platelet adhesion on the surface of biodegradable Mg substrate. (C) 2020 The Author(s). Published by Elsevier B.V.