CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression
CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression
复制标题
CircPLK1 海绵 miR-296-5p 促进三阴性乳腺癌进展
DOI：
10.2217/epi-2019-0093
复制
发表时间：
2019-08-01
期刊：
影响因子：
3.8
通讯作者：
Tang, Hailin
中科院分区：
文献类型：
--
作者：
Kong, Yanan;Yang, Lu;Tang, Hailin
目的：探讨circRNA在三阴性乳腺癌（TNBC）中的作用及其机制。材料和方法：我们进行了circRNA微阵列以探索TNBC细胞系的表达谱。通过体内外实验研究circPLK 1对TNBC肿瘤增殖和转移的影响，以及circPLK 1、miR-296- 5 p和PLK 1之间的相互作用。结果与结论：CircPLK 1在TNBC中显著上调，并且与较差的存活率相关。CircPLK 1基因敲低抑制体外细胞生长和侵袭以及体内肿瘤发生和转移。CircPLK 1-miR-296- 5 p-PLK 1轴在TNBC中通过ceRNA机制调节肿瘤进展，表明circPLK 1可作为TNBC的预后因子和新的治疗靶点。
Aim: To investigate the role of circRNAs in triple-negative breast cancer (TNBC) and the underlying mechanisms. Materials & methods: We performed circRNA microarrays to explore the expression profiles of TNBC cell lines. Experiments in vitro and in vivo were conducted to explore the effects of circPLK1 on tumor proliferation and metastasis as well as the interaction between circPLK1, miR-296-5p and PLK1 in TNBC. Results & conclusion: CircPLK1 was significantly upregulated in TNBC and associated with poor survivals. CircPLK1 knockdown inhibited cell growth and invasion in vitro as well as tumor occurrence and metastasis in vivo. CircPLK1-miR-296-5p-PLK1 axis regulates tumor progression by ceRNA mechanism in TNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC.