Central melanocortin receptors regulate insulin action
Central melanocortin receptors regulate insulin action
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DOI：
10.1172/jci12954
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发表时间：
2001-10-01
影响因子：
15.9
通讯作者：
Rossetti, L
中科院分区：
文献类型：
--
作者：
Obici, S;Feng, ZH;Rossetti, L
能量平衡和胰岛素作用密切相关。瘦素部分通过调节下丘脑中的黑皮质素途径来调节能量摄入和消耗。在这里，我们证明了黑皮质素途径对胰岛素作用和肥胖的身体分布的有效影响。清醒的大鼠在第三脑室接受为期一周的黑皮质素受体激动剂、α-黑素细胞刺激激素（α-MSH）或拮抗剂 SHU9119 输注，同时每组的食物摄入量保持恒定。 α-MSH 减少腹内脂肪，并显着增强胰岛素对葡萄糖摄取和产生的作用，而 SHU9119 则发挥相反的作用。我们的研究结果阐明了神经内分泌网络可能在能量摄入和胰岛素作用的耦合中发挥核心作用。
Energy balance and insulin action are tightly coregulated. Leptin regulates energy intake and expenditure partly by modulation of the melanocortin pathway in the hypothalamus. Here we demonstrate potent effects of the melanocortin pathway on insulin action and body distribution of adiposity. Conscious rats received week-long infusions of either a melanocortin receptor agonist, alpha -melanocyte-stimulating hormone (alpha -MSH), or antagonist, SHU9119, in the third cerebral ventricle while food intake was maintained constant in each group. alpha -MSH decreased intra-abdominal fat and markedly enhanced the actions of insulin on both glucose uptake and production, while SHU9119 exerted opposite effects. Our findings elucidate a neuroendocrine network that is likely to play a central role in the coupling of energy intake and insulin action.