Prominent expression of lysyl oxidase during mouse embryonic cardiovascular development.
Prominent expression of lysyl oxidase during mouse embryonic cardiovascular development.
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赖氨酰氧化酶在小鼠胚胎心血管发育过程中的显着表达。
DOI：
10.1002/ar.a.10002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Chu,Mon-Li
中科院分区：
文献类型：
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作者：
Tsuda,Takeshi;Pan,Te-Cheng;Evangelisti,Lucia;Chu,Mon-Li
通过小鼠心脏中的mRNA差异显示，赖氨酰氧化酶（Lox），一种催化弹性蛋白和胶原交联的关键酶，被发现在胚胎第11天（E11）和第13天（E13）之间上调。这通过半定量RT-PCR证实。我们通过原位杂交分析了其在心肌细胞、内膜垫组织、主动脉弓血管和心外膜发育中的时空表达模式。Anat Rec Part A 270 A：93-96，2003.© 2003 Wiley利斯公司
By mRNA differential display in mouse hearts,lysyl oxidase(Lox), a key enzyme catalyzing cross‐links in elastin and collagens, was found to be up‐regulated between embryonic days 11 (E11) and 13 (E13). This was confirmed by semiquantitative RT‐PCR. We analyzed its spatio‐temporal expression pattern by in situ hybridization in regard to the development of myocardial cells, endocardial cushion tissue, aortic arch vessels, and epicardium. Anat Rec Part A 270A:93–96, 2003. © 2003 Wiley‐Liss, Inc.