Oligosyndactylism, an early embryonic lethal in the mouse.
Oligosyndactylism, an early embryonic lethal in the mouse.
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少指症，小鼠早期胚胎致死现象。
DOI：
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发表时间：
1966
期刊：
影响因子：
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通讯作者：
P. V. Valen
中科院分区：
文献类型：
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作者：
P. V. Valen
在杂合子的条件下，小鼠(小鼠)的寡趾关节(Os)基因会导致所有四只脚的并趾，有时还会抑制第二指。OS/Os纯合子是不能存活的，并在怀孕第12天之前死亡(Gruneberg，1956,1961)。本研究的目的是鉴定OS/OS纯合子，并确定其死亡情况。被研究的OS小鼠的种群由伦敦大学学院动物遗传学系维护。在这项工作的后期，在纽约大学医学中心建立了一个由Gruneberg教授亲切送来的小鼠群体。在妊娠第3天至第8天，对来自Os/+×Os/+和Os/+×+/+配对的胚胎进行检查。用标准阴道塞法测定年龄。以发现阴道塞子的早晨为第0天。
In heterozygous condition, the gene for oligosyndactylism ( Os ) in the mouse ( Mus musculus ) causes syndactylism on all four feet and sometimes suppression of digit 2. Os/Os homozygotes are inviable and die before the 12th day of gestation (Gruneberg, 1956, 1961). The present study was initiated to identify the Os/Os homozygote and to establish the circumstances of its death. The stock of Os mice studied was maintained in the Department of Animal Genetics, University College London. During the later part of the work, a colony was established at New York University Medical Center from mice kindly sent by Professor Gruneberg. Embryos from Os / + × Os / + and from Os / + × + / + matings were examined between the 3rd and 8th day of gestation. Age was determined by the standard vaginal plug method. The morning on which a vaginal plug was found was taken as day 0.