Novel asymmetric through-hole array microfabricated on a silicon plate for formulating monodisperse emulsions
Novel asymmetric through-hole array microfabricated on a silicon plate for formulating monodisperse emulsions
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DOI：
10.1021/la050915x
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发表时间：
2005-08-16
期刊：
影响因子：
3.9
通讯作者：
Nakajima, M
中科院分区：
文献类型：
--
作者：
Kobayashi, I;Mukataka, S;Nakajima, M
We have proposed a novel microchannel (MC) structure for formulating monodisperse emulsions. The emulsification device is a silicon array of microfabricated, asymmetric through-holes with a slit and a circular channel (an asymmetric straight-through MC). The asymmetric through-holes of a uniform size stably yielded monodisperse emulsions with average droplet diameters of 35-41 mu m and coefficients of variation of less than 2% by forcing the to-be-dispersed phase into the continuous phase via the through-holes. Their asymmetry enabled the stable formation of monodisperse emulsion droplets by spontaneous transformation, even using a to-be-dispersed phase with a very low viscosity below I mPa s. Additionally, the asymmetric straight-through MC with a high-density through-hole layout has the potential for high-throughput formulation of monodisperse emulsions.
