PROMIS(®) pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions.
PROMIS(®) pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions.
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DOI：
10.1007/s11136-015-0953-3
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Varni JW
中科院分区：
文献类型：
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作者：
DeWalt DA;Gross HE;Gipson DS;Selewski DT;DeWitt EM;Dampier CD;Hinds PS;Huang IC;Thissen D;Varni JW
使用疾病严重程度指标，对美国国立卫生研究院（NIH）患者报告结局测量信息系统（PROMIS®）的8个8-17岁儿童自我报告量表在6种儿童慢性健康状况中进行比较分析。患有哮喘、癌症、慢性肾病、肥胖、风湿性疾病和镰状细胞病的儿科患者（N = 1，454）完成了PROMIS儿科活动性、上肢功能、抑郁症状、焦虑、愤怒、同伴关系、疼痛干扰和疲劳自我报告量表中的项目。通过使用针对每种疾病特征的严重程度标志物，基于疾病严重程度检查组间差异，对6种儿科慢性健康状况进行比较。还对最近住院和未住院的儿童进行了疾病比较。总的来说，每种慢性健康状况的自我报告的健康结果存在差异，疾病严重程度较高的患者表现出更差的结果。在健康状况方面，当最近住院的儿童与过去六个月内没有住院的儿童进行比较时，我们发现除了愤怒之外，所有PROMIS领域的预期方向都存在显着差异。PROMIS措施区分几种慢性疾病中不同的临床意义的亚组。需要进一步的研究来确定PROMIS儿科量表随时间变化的反应性。
To conduct a comparative analysis of eight pediatric self-report scales for ages 8-17 years from the National Institutes of Health (NIH) Patient Reported Outcomes Measurement Information System (PROMIS®) in six pediatric chronic health conditions, using indicators of disease severity. Pediatric patients (N = 1,454) with asthma, cancer, chronic kidney disease, obesity, rheumatic disease, and sickle cell disease completed items from the PROMIS pediatric mobility, upper extremity functioning, depressive symptoms, anxiety, anger, peer relationships, pain interference, and fatigue self-report scales. Comparisons within the six pediatric chronic health conditions were conducted by examining differences in groups based on disease severity using markers of severity that were specific to characteristics of each disease. A comparison was also made across diseases between children who had been recently hospitalized and those who had not. In general, there were differences in self-reported health outcomes within each chronic health condition, with patients who had higher disease severity showing worse outcomes. Across health conditions, when children with recent hospitalizations were compared with those who had not been hospitalized in the past six months, we found significant differences in the expected directions for all PROMIS domains, except anger. PROMIS measures discriminate between different clinically meaningful subgroups within several chronic illnesses. Further research is needed to determine the responsiveness of the PROMIS pediatric scales to change over time.