Gene conversion and concerted evolution in bacterial genomes.
Gene conversion and concerted evolution in bacterial genomes.
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DOI：
10.1016/j.fmrre.2004.10.004
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发表时间：
2005
影响因子：
11.3
通讯作者：
G. Santoyo;D. Romero
中科院分区：
文献类型：
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作者：
G. Santoyo;D. Romero
基因转化被定义为同源序列之间的非互惠信息传递。尽管存在建立非互惠关系的方法学问题，但在各种细菌中已经证明了基因转换。除了重复基因突变的高频逆转的例子外，细菌基因组中的基因转换也与多基因家族的协同进化有关。基因转换在抗原变异的产生中也起着至关重要的作用，这是一种有趣的机制，一些细菌病原体能够通过这种机制避开宿主免疫系统。在这篇综述中，我们分析了细菌基因转换的例子(其中一些是在当前的基因组革命中产生的)，以及解释基因转换及其与交叉的关联的分子模型。
Gene conversion is defined as the non-reciprocal transfer of information between homologous sequences. Despite methodological problems to establish non-reciprocity, gene conversion has been demonstrated in a wide variety of bacteria. Besides examples of high-frequency reversion of mutations in repeated genes, gene conversion in bacterial genomes has been implicated in concerted evolution of multigene families. Gene conversion also has a prime importance in the generation of antigenic variation, an interesting mechanism whereby some bacterial pathogens are able to avoid the host immune system. In this review, we analyze examples of bacterial gene conversion (some of them spawned from the current genomic revolution), as well as the molecular models that explain gene conversion and its association with crossovers.