Central Nervous System Fibroblast-Like Cells in Stroke and Other Neurological Disorders.
Central Nervous System Fibroblast-Like Cells in Stroke and Other Neurological Disorders.
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DOI：
10.1161/strokeaha.120.033431
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发表时间：
2021-07
期刊：
影响因子：
8.3
通讯作者：
Yao Y
中科院分区：
文献类型：
--
作者：
Xu L;Yao Y
成纤维细胞是结缔组织中最常见的细胞类型。在中枢神经系统中，成纤维细胞样细胞主要位于脑膜和血管周围的Virchow-Robin间隙。这些成纤维细胞样细胞的起源及其在中枢神经系统发育和病理条件中的功能在很大程度上仍然未知。本文首先介绍了中枢神经系统成纤维细胞样细胞的解剖位置和分子标记。接下来，将讨论成纤维细胞样细胞在中枢神经系统发育和神经系统疾病（包括中风、中枢神经系统外伤性损伤和其他神经系统疾病）中的功能。第三，总结了该领域当前面临的挑战和未来的发展方向。我们希望提供一个综合综述，以刺激未来对中枢神经系统成纤维细胞样细胞的研究。
Fibroblasts are the most common cell type of connective tissues. In the CNS, fibroblast-like cells are mainly located in the meninges and perivascular Virchow-Robin space. The origins of these fibroblast-like cells and their functions in both CNS development and pathological conditions remain largely unknown. In this review, we first introduce the anatomical location and molecular markers of CNS fibroblast-like cells. Next, the functions of fibroblast-like cells in CNS development and neurological disorders, including stroke, CNS traumatic injuries, and other neurological diseases, are discussed. Third, current challenges and future directions in the field are summarized. We hope to provide a synthetic review that stimulates future research on CNS fibroblast-like cells.