Decreased total venous capacity in Goldblatt hypertensive rats.
Decreased total venous capacity in Goldblatt hypertensive rats.
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Goldblatt 高血压大鼠的总静脉容量降低。
DOI：
10.1152/ajpheart.1981.240.4.h487
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
E. Frohlich
中科院分区：
文献类型：
--
作者：
J. Yamamoto;N. Trippodo;A. Macphee;E. Frohlich
在清醒大鼠的早期，中期和慢性阶段的一肾，一夹Goldblatt高血压的平均循环充盈压（MCFP）和总血容量（BV）进行了测定。MCFP由短暂停循环期间的动脉和静脉平台压确定，这是通过充盈留置的右心房球囊完成的。根据血浆容量（125 I-白蛋白）、动脉血细胞比容和F细胞因子确定BV。与单肾假手术组相比，单肾、单夹Goldblatt高血压组在夹闭后3、14和28天的MCFP显着增加，而在任何这些时间段，高血压组和正常血压组之间的BV均未观察到显着差异。在BV快速变化之前和之后立即通过测量MCFP估计的总血管顺应性在所有单肾一夹Goldblatt高血压组中显著降低。这些结果表明，静脉收缩增加，全身静脉容量下降，在所有三个阶段的一肾，一夹Goldblatt高血压研究。导致单肾一夹型高血压静脉收缩增加的机制仍有待阐明。
Mean circulatory filling pressure (MCFP) and total blood volume (BV) were determined in conscious rats during the early, intermediate, and chronic phases of one-kidney, one-clip Goldblatt hypertension. MCFP was determined from arterial and venous plateau pressures during brief circulatory arrest, which was accomplished by inflating an indwelling right atrial balloon. BV as determined from plasma volume (125I-albumin), arterial hematocrit, and the F-cells factor. As compared with one-kidney sham groups, MCFP was significantly increased in one-kidney, one-clip Goldblatt hypertensive groups at 3, 14, and 28 days postclipping, whereas no significant differences in BV between hypertensive and normotensive groups were observed at any of these time periods. Total vascular compliance, estimated by measuring MCFP before and immediately after rapid BV changes, was significantly decreased in all one-kidney, one-clip Goldblatt hypertensive groups. These results indicate that venous constriction was increased and whole-body venous capacity was decreased in all three phases of one-kidney, one-clip Goldblatt hypertension studied. The mechanism leading to increased venous constriction in one-kidney, one-clip Goldblatt hypertension remains to be elucidated.