Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk.
Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk.
复制标题
DOI：
10.1111/j.1749-6632.2009.05038.x
复制
发表时间：
2009-10
影响因子：
5.2
通讯作者：
Bruick RK
中科院分区：
文献类型：
--
作者：
Salahudeen AA;Bruick RK
Though iron and oxygen are required to sustain essential biological processes, an excess of either can result in oxidative stress. Therefore, mammals tightly regulate cellular and systemic iron and oxygen homeostasis. At the cellular level, the hypoxia-inducible transcription factors (HIFs) are key mediators of oxygen homeostasis through their regulation of genes involved in anaerobic metabolism and oxygen delivery, among others. Iron regulatory proteins (IRPs) largely govern cellular iron homeostasis through their effects on the translation and stability of mRNAs involved in iron uptake, utilization, export, and storage. Here, we describe regulatory factors for each pathway that sense both iron and oxygen availability and coordinate the maintenance of mammalian iron and oxygen homeostasis at both the cellular and systemic levels.
登录
查看更多内容
影响因子：
56.9
作者：
Jaakkola, P;Mole, DR;Ratcliffe, PJ
通讯作者：
Ratcliffe, PJ
影响因子：
20.3
作者：
Manalo, DJ;Rowan, A;Semenza, GL
通讯作者：
Semenza, GL
DOI：
10.1073/pnas.192342099
发表时间：
2002-10-15
影响因子：
11.1
作者：
Ivan, M;Haberberger, T;Kaelin, WG
通讯作者：
Kaelin, WG
影响因子：
20.3
作者：
Galy, B;Ferring, D;Hentze, MW
通讯作者：
Hentze, MW
影响因子：
56.9
作者：
Meyron-Holtz, EG;Ghosh, MC;Rouault, TA
通讯作者：
Rouault, TA