Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary.
Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary.
复制标题
匈牙利肺炎链球菌临床分离株抗生素耐药性发生率极高。
DOI：
10.1093/infdis/163.3.542
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Tomasz,A
中科院分区：
文献类型：
--
作者：
Marton,A;Gulyas,M;Munoz,R;Tomasz,A
1988 年和 1989 年在匈牙利收集的肺炎球菌分离株抗生素耐药性流行病学调查表明，所有分离株中多达 58% 和儿童分离株中 70% 对青霉素具有耐药性。这些数字甚至超过了迄今为止西班牙和南非同期报告的最高值。几乎或超过 70% 的青霉素耐药菌株也对四环素、红霉素和复方新诺明耐药，约 30% 对氯霉素耐药。静脉注射氨苄西林（30 mg/kg）不会干扰引入实验性脑膜炎兔模型的三种耐药菌株在脑脊液中的生长。没有显示出耐药菌株（β-内酰胺酶活性）。代表性的高耐药菌株含有改变的青霉素结合蛋白（低青霉素亲和力和异常分子大小），并且对青霉素的裂解和杀伤作用也具有耐药性。
An epidemiologic survey of antibiotic resistance among pneumococcal isolates collected during 1988 and 1989 in Hungary indicated that as many as 58% of all isolates and 70% of isolates from children were resistant to penicillin. These figures surpass even the highest values reported thus far for Spain and South Africa for the same period. Almost or more than 70% of the penicillin resistant isolates were also resistant to tetracycline, erythromycin, and cotrimoxazole and ∼30% to chloramphenicol. Intravenous administration of ampicillin (30 mg/kg) did not interfere with the growth in the cerebrospinal fluid of three resistant strains introduced into the rabbit model of experimental meningitis. No resistant strain showed (β-lactamase activity. A representative highly resistant strain contained altered penicillin-binding proteins (low penicillin affinities and abnormal molecular sizes) and was also resistant to the lytic and killing effects of penicillin.