Dynamic programming generation of boundaries of local coordinatized submanifolds in the neocortex: application to the planum temporale
Dynamic programming generation of boundaries of local coordinatized submanifolds in the neocortex: application to the planum temporale
复制标题
DOI：
10.1016/s1053-8119(03)00238-6
复制
发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Miller, MI
中科院分区：
文献类型：
--
作者：
Ratnanather, JT;Barta, PE;Miller, MI
动态规划用于定义皮层亚流形的边界，重点关注颞上回（STG）的颞平面（PT），这与多种神经精神疾病有关。为此，使用自动化方法从包含STG的10个高分辨率MRI子体积ROI掩模中生成PT歧管。开发了从原始MRI脑部扫描中定义ROI子体积掩模的程序。然后使用贝叶斯分割将亚体积分割为脑脊液、灰质（GM）和白质（WM）。利用GM和WM概率相等的强度值进行三维等等高线重建代表STG皮质表面的三角图，从而计算图上每个点的主曲率。动态规划用于通过跟踪从Heschl's gyrus （HG）的岛后端到STG的主曲线来描绘PT流形，沿着后STG一直到分支的开始，再回到HG的岛后端。然后在PT流形上定义一个坐标系。起点由HG的后岛端确定，y轴穿过STG后部分支开始的点。STG中GM的自动标记具有鲁棒性，贝叶斯和人工分割之间的距离在0.001-0.12范围内为L-1 （n = 20）。PT重建也具有鲁棒性，重建PT的90%的顶点在半自动化轮廓的约1体素（n = 20）内。最后，通过重复重建得到的左侧PT和右侧PT的表面积的可靠度指数分别为0.96和0.94，显示了动态规划在PT上定义坐标系统的鲁棒性，为神经精神疾病的研究提供了一种具有潜在意义的方法。(C) 2003 Elsevier Inc.版权所有。
Dynamic programming is used to define boundaries of cortical submanifolds with focus on the planum temporale (PT) of the superior temporal gyrus (STG), which has been implicated in a variety of neuropsychiatric disorders. To this end, automated methods are used to generate the PT manifold from 10 high-resolution MRI subvolumes ROI masks encompassing the STG. A procedure to define the subvolume ROI masks from original MRI brain scans is developed. Bayesian segmentation is then used to segment the subvolumes into cerebrospinal fluid, gray matter (GM), and white matter (WM). 3D isocontouring using the intensity value at which there is equal probability of GM and WM is used to reconstruct the triangulated graph representing the STG cortical surface, enabling principal curvature at each point on the graph to be computed. Dynamic programming is used to delineate the PT manifold by tracking principal curves from the retro-insular end of the Heschl's gyrus (HG) to the STG, along the posterior STG up to the start of the ramus and back to the retro-insular end of the HG. A coordinate system is then defined on the PT manifold. The origin is defined by the retro-insular end of the HG and the y-axis passes through the point on the posterior STG where the ramus begins. Automated labeling of GM in the STG is robust with L-1 distances between Bayesian and manual segmentation in the range 0.001-0.12 (n = 20). PT reconstruction is also robust with 90% of the vertices of the reconstructed PT within about 1 voxel (n = 20) from semiautomated contours. Finally, the reliability index (based on interrater intraclass correlation) for the surface area derived from repeated reconstructions is 0.96 for the left PT and 0.94 for the right PT, thus demonstrating the robustness of dynamic programming in defining a coordinate system on the PT. It provides a method with potential significance in the study of neuropsychiatric disorders. (C) 2003 Elsevier Inc. All rights reserved.