The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram - A population-based study of four decades
The prevalence, incidence and prognostic value of the Brugada-type electrocardiogram - A population-based study of four decades
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DOI：
10.1016/s0735-1097(01)01421-8
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发表时间：
2001-09-01
影响因子：
24
通讯作者：
Yano, K
中科院分区：
文献类型：
--
作者：
Matsuo, K;Akahoshi, M;Yano, K
目的 我们试图证明 Brugada 型心电图 (ECG) 在一般人群中的患病率、发生率和预后价值。 背景 Brugada 综合征的特征是右束支传导阻滞和右心前导联 ST 段抬高，以及心室颤动引起的猝死。然而，Brugada 型心电图的自然史仍不清楚。 方法 我们调查了 1958 年年龄< 50 岁的 4,788 名受试者（1,956 名男性和 2,832 名女性），并在 1999 年之前每两年进行一次健康检查，包括心电图。 Brugada 型心电图定义为导联 V-1 中的终末 r' 波且 ST 段抬高大于或等于 V-1 和 V-2 导联中为 0.1 mV。意外死亡定义为猝死或原因不明的意外死亡。结果Brugada型心电图病例共32例；患病率和发病率分别为每10万人年146.2人和每10万人年14.2人。男性的发病率是女性的九倍，就诊时的平均年龄为 45 +/- 10.5 岁。在大多数情况下，Brugada 型心电图会间歇性出现，并且在 26% 的意外死亡受试者中发现。 Cox 生存分析显示，Brugada 型心电图受试者的意外死亡死亡率显着高于对照受试者 (p < 0.01)。在有晕厥病史的 Brugada 型心电图受试者中，意外死亡更为常见 (p < 0.05)。结论 Brugada 型心电图在日本成年人群中并不是一种非常罕见的疾病。具有 Brugada 型心电图的受试者意外死亡的风险增加。 (C) 2001 年由美国心脏病学会发布。
OBJECTIVES We sought to demonstrate the prevalence, incidence and prognostic value of the Brugada-type electrocardiogram (ECG) in a general population.BACKGROUND The Brugada syndrome is characterized by evidence of right bundle branch block and ST segment elevation in the right precordial leads, as well as sudden death caused by ventricular fibrillation. However, the natural history of the Brugada-type ECG remains unclear.METHODS We investigated 4,788 subjects (1,956 men and 2,832 women) who were < 50 years old in 1958 and had undergone biennial health examinations, including electrocardiography, through 1999. The Brugada-type ECG was defined as a terminal r ' wave in lead V-1 and ST segment elevation greater than or equal to0.1 mV in leads V-1 and V-2. Unexpected death was defined as sudden death or unexplained accidental death.RESULTS There were a total of 32 Brugada-type ECG cases; the prevalence and incidence were 146.2 in 100,000 persons and 14.2 persons per 100,000 person-years, respectively. The incidence was nine times higher among men than women, and the average age at presentation was 45 +/- 10.5 years. The Brugada-type ECG appeared intermittently in most cases and was found in 26% of subjects who died unexpectedly. Cox survival analysis revealed that mortality from unexpected death was significantly higher in subjects with a Brugada-type ECG than in control subjects (p < 0.01). Unexpected deaths were more frequent among subjects with the Brugada-type ECG who had a history of syncope (p < 0.05).CONCLUSIONS The Brugada-type ECG is not a very rare condition in the adult Japanese population. Subjects with a Brugada-type ECG have an increased risk of unexpected death. (C) 2001 by the American College of Cardiology.