Nonconvulsive Status Epilepticus Value of a Benzodiazepine Trial for Predicting Outcomes
Nonconvulsive Status Epilepticus Value of a Benzodiazepine Trial for Predicting Outcomes
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DOI：
10.1097/nrl.0b013e31822f688c
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发表时间：
2011-11-01
期刊：
影响因子：
1.2
通讯作者：
Barry, Elizabeth
中科院分区：
文献类型：
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作者：
Hopp, Jennifer L.;Sanchez, Ana;Barry, Elizabeth
目的：非惊厥癫痫持续状态(NCSE)的管理面临许多挑战，早期预测患者预后的额外措施将使其受益。在这里，我们评估了一项急性抗癫痫药物试验的临床和脑电反应，作为预测疑似NCSE患者预后的补充指标。方法：我们分析了所有到我们神经科服务的疑似NCSE患者，这些患者都是通过标准的急性静脉注射(IV)苯二氮(BDZ)方案进行评估的。我们将患者对BDZ试验的临床和脑电(EEG)反应与随后的结果相关联，包括存活、意识恢复和出院时的功能状态。结果：从1990年到2001年，我们确定了62名NCSE患者，他们最初接受了急性静脉注射BDZ试验的评估。22例患者(35%)临床反应良好，意识改善，而40例(65%)临床无效。所有阳性的临床应答者(100%)都存活下来，恢复意识，并表现出良好的功能结果。相比之下，结果明显更差(P
Objectives: Managing nonconvulsive status epilepticus (NCSE) poses many challenges that would benefit from additional early measures to predict patient outcomes. Here, we evaluate clinical and electro-encephalographic responses to an acute antiepileptic drug trial as an added measure for predicting outcomes in patients presenting with suspected NCSE.Methods: We analyzed all patients referred to our Neurology Service with suspected NCSE assessed by a standard acute intravenous (IV) benzodiazepine (BDZ) protocol. We correlated patients' clinical and electrographic (EEG) responses to the BDZ trial with their subsequent outcomes, including survival, recovery of consciousness, and functional status at hospital discharge.Results: From 1990 to 2001, we identified 62 patients with NCSE who were initially evaluated with an acute IV BDZ protocol trial. A favorable clinical response with improvement in consciousness was observed in 22 patients (35%), whereas 40 (65%) were clinical nonresponders. All of the positive clinical responders (100%) survived, recovered consciousness, and exhibited good functional outcomes. In contrast, outcomes were significantly poorer (P