Advances of Wnt signalling pathway in dental development and potential clinical application

Advances of Wnt signalling pathway in dental development and potential clinical application
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Wnt信号通路在牙齿发育中的研究进展及潜在临床应用

DOI:
10.1080/15476278.2019.1656996
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发表时间:
2019-09
期刊:
影响因子:
2.3
通讯作者:
Liu Shangfeng
Liu Shangfeng
中科院分区:
工程技术4区
文献类型:
--
作者:
Lu Xi;Yang Jun;Zhao Shouliang;Liu Shangfeng

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Wnt信号通路在胚胎发生、组织稳态和伤口修复等生物发育过程中被广泛研究。众所周知,Wnt信号通路在牙齿发育过程中起着重要作用。本文总结了Wnt信号通路在牙齿起始、牙冠形态发生、牙根形成过程中的作用,并讨论了Wnt调节剂的治疗潜力。
ABSTRACT Wnt signalling pathway is widely studied in many processes of biological development, like embryogenesis, tissue homeostasis and wound repair. It is universally known that Wnt signalling pathway plays an important role in tooth development. Here, we summarized the function of Wnt signalling pathway during tooth initiation, crown morphogenesis, root formation, and discussed the therapeutic potential of Wnt modulators.
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