Bacterial meningitis in Malawian adults: Pneumococcal disease is common, severe, and seasonal
Bacterial meningitis in Malawian adults: Pneumococcal disease is common, severe, and seasonal
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DOI：
10.1086/313910
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发表时间：
2000-07-01
影响因子：
11.8
通讯作者：
Read, RC
中科院分区：
文献类型：
--
作者：
Gordon, SB;Walsh, AL;Read, RC
我们前瞻性地收集了1998年4月1日至1999年3月31日我们在马拉维布兰太尔的单位报告的所有实验室确认的脑膜炎患者的实验室细节和结果数据，共有502名患者患有脑膜炎；最常见的致病菌是新生隐球菌和肺炎链球菌。这一模式可能反映了当地人类免疫缺陷病毒(HIV)的血清阳性率(31%)，与1974年的模式不同，当时脑膜炎奈瑟菌是最常见的分离物，自1974年以来，脑膜炎病例数量每年增加8倍，因脑膜炎住院的比例翻了一番。肺炎球菌脑膜炎患者的住院死亡率为61%，总体死亡率为41%。尽管这些脑膜炎病例感染病原体的模式与艾滋病毒有关，这种情况的发病率也有所增加，但有证据表明，肺炎球菌脑膜炎的典型季节性模式被保留下来，这种模式在寒冷、干燥的季节达到顶峰。
We prospectively collected laboratory details and outcome data on ail patients with laboratory-confirmed cases of meningitis that presented Co our unit in Blantyre, Malawi, from 1 April 1998 through 31 March 1999, There were 502 patients with cases of meningitis; the most common causative organisms were Cryptococcus neoformans and Streptococcus pneumoniae. This pattern probably reflects the local human immunodeficiency virus (HIV) seroprevalence (31%) and is different from the pattern in 1974, when Neisseria meningitidis was the most common isolate, There has been an 8-fold increase in the number of meningitis cases per year since 1974, and a doubling of the percentage of medical admissions due to meningitis. The inpatient mortality rate among patients with cases of pneumococcal meningitis was 61%, and in the group as a whole was 41%. Despite the HIV-related pattern of infecting pathogens among these cases of meningitis and the increased incidence of the condition, there was evidence that the typical seasonal pattern of pneumococcal meningitis, which peaks in the cold, dry season, was preserved.