Association between C-reactive protein and pre-diabetic status in a Chinese Han clinical population
Association between C-reactive protein and pre-diabetic status in a Chinese Han clinical population
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DOI：
10.1002/dmrr.923
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发表时间：
2009-03-01
影响因子：
8
通讯作者：
Liu, Liegang
中科院分区：
文献类型：
--
作者：
Lin, Jie;Zhang, Muxun;Liu, Liegang
背景 C反应蛋白（CRP）已被证明与2型糖尿病相关，但CRP是否是亚洲人血糖异常的基础尚不清楚，因为他们的体重指数（BMI）水平比西方人低得多。 方法 在这项基于临床的横断面研究中，比较了1730名中国汉族男性和女性（包括1258名糖耐量正常的受试者）不同BMI水平和不同性别的CRP与高血糖之间的关系。 (NGT)、126 名空腹血糖受损 (IFG) 受试者和 346 名糖耐量受损 (IGT) 受试者。孤立性IFG或IGT受试者均为初诊且未使用抗糖尿病药物。结果与NGT受试者相比，IGT和IFG受试者的BMI、空腹血糖、稳态模型评估胰岛素抵抗（HOMA-IR）、血压、血脂异常和血清CRP水平升高。在分层分析中，CRP 水平升高与不同 BMI 层中 IGT 和 IFG 的患病率密切相关。调整性别、年龄、BMI、教育程度、饮酒、吸烟、高血压状况、休闲体育活动和职业体育活动后，IFG 的 CRP 四分位数 OR 分别为 1.00、1.43、2.14 和 2.29（趋势 P：0.025），IGT 的 OR 为 1.00、1.85、2.32 和 2.79（趋势 P： 0.012). 结论 这些结果支持这样的假设：即使在较瘦且健康的人群中，慢性炎症可能与高血糖的发生有关。版权所有 (c) 2008 John Wiley & Sons, Ltd.
Background C-reactive protein (CRP) has been showed to be associated with type 2 diabetes mellitus, but whether CRP underlies glucose disorders in Asian people is still unclear, for they have much lower body mass index (BMI) levels than these Westerns in previous studies.Method In this clinical-based cross-sectional study, the association between CRP and hyperglycaemia in different BMI levels and different gender was compared among 1730 Chinese Han men and women, including 1258 subjects with normal glucose tolerance (NGT), 126 subjects with impaired fasting glucose (IFG) and 346 subjects with impaired glucose tolerance (IGT). Subjects with isolated IFG or IGT were all newly diagnosed and did not use anti-diabetic drugs.Results Compared with subjects with NGT, BMI, fasting blood glucose, homoeostatis model assessment insulin resistance (HOMA-IR), blood pressure, dyslipidemia, and serum CRP levels were increased in subjects with IGT and IFG. In stratified analyses, increasing CRP levels were strongly associated with prevalence of IGT and IFG in different BMI strata. After adjustment for sex, age, BMI, education, alcohol consumption, smoking, hypertension status, recreational physical activity and occupational physical activity, the ORs across quartiles of CRP were 1.00, 1.43, 2.14 and 2.29 for IFG (P for trend: 0.025) and 1.00, 1.85, 2.32 and 2.79 for IGT (P for trend: 0.012).Conclusion These results support the hypothesis that chronic inflammation may be involved in the development of hyperglycaemia, even though in a thinner and healthy population. Copyright (c) 2008 John Wiley & Sons, Ltd.