RADIATION SENSITIVITY AND DNA-REPAIR IN CAENORHABDITIS-ELEGANS STRAINS WITH DIFFERENT MEAN-LIFE SPANS
RADIATION SENSITIVITY AND DNA-REPAIR IN CAENORHABDITIS-ELEGANS STRAINS WITH DIFFERENT MEAN-LIFE SPANS
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DOI：
10.1016/s0165-7992(98)90003-3
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发表时间：
1988-06-01
期刊：
影响因子：
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通讯作者：
MITCHELL, D
中科院分区：
文献类型：
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作者：
HARTMAN, PS;SIMPSON, VJ;MITCHELL, D
对三种DNA损伤剂（UV和γ-辐射，甲磺酸甲酯）在秀丽隐杆线虫的四种重组近交（RI）菌株中测量，所述菌株的平均寿命为13至30.9天，以及在用于衍生这些RI的野生型菌株中测量。在几个阶段的发展周期的敏感性进行了测试。平均寿命与这3种药物的致死效应之间无显著相关性。两个UV辐射诱导的DNA光产物的切除也进行了测量。长寿命的菌株并不比短寿命的菌株更有修复能力。这些数据表明，DNA修复在C.优美的
The sensitivities to three DNA damaging agents (UV and .gamma.-radiation, methyl methanesulfonate) were measured in four recombinant inbred (RI) strains of Caenorhabditis elegans with mean life spans ranging from 13 to 30.9 days, as well as in the wild-type strains used to derive these RI''s. Sensitivities at several stages in the developmental cycle were tested. There were no significant correlations between mean life span and the lethal effects of these 3 agents. Excision of two UV-radiation-induced DNA photoproducts was also measured. Long-lived strains were no more repair competent than shorter-lived strains. These data indicate that DNA repair plays at best a minor role in the aging process of C. elegans.