Age-related changes of motor evoked potentials in healthy humans: Non-invasive evaluation of central and peripheral motor tracts excitability and conductivity
Age-related changes of motor evoked potentials in healthy humans: Non-invasive evaluation of central and peripheral motor tracts excitability and conductivity
复制标题
健康人运动诱发电位与年龄相关的变化：中枢和外周运动束兴奋性和传导性的无创评估
DOI：
10.1016/0006-8993(92)91256-e
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
M. Caramia
中科院分区：
文献类型：
--
作者：
P. Rossini;M. Desiato;M. Caramia
在年轻（25例受试者，年龄范围16-35岁）和老年（40例受试者，51-86岁）健康志愿者人群中进行皮质脊髓束神经传播和兴奋性阈值的比较分析。运动诱发电位（MEP）记录从手和脚肌肉后，经颅磁刺激（TCS）在完全放松和主动收缩的目标肌肉。阈值强度对应于刺激器的输出引出阈MEP在约50%的刺激放松。结果表明，老年人手、足的磁TCS阈值分别为44 ± 6.4%和66 ± 10.1%，明显高于青年人（39 ± 3.5%和56 ± 6.7%，P< 0.001）。此外，这一指数随着年龄的增长而逐渐增加（P< 0.001），而沿中央运动束的传播时间沿着并不平行于这种年龄相关的趋势。
A comparative analysis of the corticospinal tract nervous propagation and excitability threshold was carried out in young (25 subjects, age range 16–35 years) and in elderly (40 subjects, 51–86 years) populations of healthy volunteers. Motor evoked potentials (MEPs) were recorded from the hand and foot muscles following transcranial magnetic stimulation (TCS) during complete relaxation and active contraction of the target muscles. Threshold intensities corresponded to the stimulator's output eliciting liminal MEPs in about 50% of stimuli during relaxation. It was found that threshold values of magnetic TCS were significantly higher in the elderly (44 ± 6.4 vs 39 ± 3.5% for the hand; 66 ± 10.1% vs 56 ± 6.7% for the foot;P< 0.001) than in the young subjects. Moreover, this index progressively increased with age (P< 0.001), whilst the propagation time along the central motor tracts did not parallel such an age-related trend.