Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study
Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study
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DOI：
10.1016/j.envres.2017.10.014
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发表时间：
2018-01-01
影响因子：
8.3
通讯作者：
Kannan, Kurunthachalam
中科院分区：
文献类型：
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作者：
Khalil, Naila;Ebert, James R.;Kannan, Kurunthachalam
背景和目的：全氟烷基物质（PFAS），包括全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA），与成人骨骼不良和代谢变化有关。然而，PFAS 与儿童骨骼健康的关系尚未得到充分研究。考虑到它们作为内分泌干扰物的作用，我们研究了四种 PFAS 与儿童骨骼健康的关系。方法：在一项横断面试点研究中，俄亥俄州代顿儿童医院招募了 48 名 8-12 岁的肥胖儿童。完成了血清的人体测量、临床和生化评估。通过 UPLC-ESI-MS/MS 测量血清 PFAS。在 23 名儿童的子集中，使用跟骨定量超声 (QUS) 测量骨骼健康参数。结果：虽然 PFAS 暴露与骨骼健康参数呈一致的负相关关系，但在测试的四种 PFAS 中，只有 PFNA 显示与骨骼参数显着负相关（β [95% CI], = - 72.7 [- 126.0, - 19.6], p = .010）。 PFNA 还与收缩压升高 (p = .008)、低密度脂蛋白胆固醇 (LDL-C; p < .001) 和总胆固醇 (TC; p = .014) 升高相关。此外，PFOA 和 PFOS 都预测 LDL-C 升高，PFOA 也预测 TC 升高。在此分析中，PFAS 与甲状腺激素、25-羟基维生素 D、肝酶或葡萄糖稳态没有很强的相关性。结论：肥胖儿童的 PFAS 暴露可能在不良骨骼和心血管风险状况中发挥作用。
Background and objective: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children.Methods: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio. Anthropometric, clinical and biochemical assessments of serum were completed. Serum PFASs were measured by UPLC-ESI-MS/MS. In a subset of 23 children, bone health parameters were measured using calcaneal quantitative ultrasound (QUS).Results: While PFASs exposure was associated with a consistent negative relationship with bone health parameters, among four PFASs tested, only PFNA showed a significant negative relationship with bone parameter (beta [95% CI], = - 72.7 [- 126.0, - 19.6], p = .010). PFNA was also associated with raised systolic blood pressure (p = .008), low density lipoprotein cholesterol (LDL-C; p < .001), and total cholesterol (TC; p = .014). In addition, both PFOA and PFOS predicted elevation in LDL-C, and PFOA predicted increased TC, as well. In this analysis, PFASs were not strongly related to thyroid hormones, 25-hydroxy vitamin D, liver enzymes, or glucose homeostasis.Conclusion: PFASs exposure in obese children may play a role in adverse skeletal and cardiovascular risk profiles.