Immunoprecipitation of [3H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies
Immunoprecipitation of [3H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies
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DOI：
10.1128/aac.45.8.2397-2399.2001
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发表时间：
2001-08-01
影响因子：
4.9
通讯作者：
Meshnick, SR
中科院分区：
文献类型：
--
作者：
Bhisutthibhan, J;Meshnick, SR
青蒿素及其衍生物是含有内过氧化物的抗疟药，似乎与恶性疟原虫翻译控制肿瘤蛋白（TCTP）同源物原位形成加合物。使用重组 TCTP 抗体进行的免疫沉淀表明，单体和二聚体 TCTP 都可能形成加合物。
Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.