Epidemiologic study of 203 sibling pairs with Parkinson's disease - The GenePD study
Epidemiologic study of 203 sibling pairs with Parkinson's disease - The GenePD study
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DOI：
10.1212/wnl.58.1.79
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发表时间：
2002-01-08
期刊：
影响因子：
9.9
通讯作者：
Myers, RH
中科院分区：
文献类型：
--
作者：
Maher, NE;Golbe, LI;Myers, RH
目的：探讨帕金森病兄弟姐妹的家庭聚集性及影响发病年龄的因素。方法：作为GenePD研究的一部分，收集有PD的同胞对(n=203)。收集和分析标准化的家族史、病史和危险因素数据。结果：发病的平均年龄为61.4岁，性别、接触咖啡、酒精或杀虫剂的情况没有差异。头部创伤与发病较早(P=0.03)和使用复合维生素的发病较晚(P=0.007)有关。兄弟姐妹间发病年龄相关显著(r=0.56，P=0.001)，且大于发病年份间的相关性(r=0.29)。兄弟姐妹之间的平均发病年龄差异为8.7岁(范围从0到30岁)。女性性行为与帕金森病亲属发病频率的增加有关。受影响的父母(7.0%)和兄弟姐妹(5.1%)的频率高于配偶(2.0%)。结论：在帕金森病的兄弟姐妹中，发病年龄与发病年份的相似性更大，亲生亲属的风险高于患者配偶的风险，这支持了帕金森病的遗传成分。这一系列中的兄弟姐妹的风险比随机系列的帕金森病病例中看到的更高；然而，这一样本中的患者具有与通常所见的帕金森病相似的发病年龄和性别分布。这些分析表明，影响外显的因素对于了解这种疾病是至关重要的。
Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (P = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, P = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.