Long-Term Health-Related Quality of Life in German Patients with Juvenile Idiopathic Arthritis in Comparison to German General Population
Long-Term Health-Related Quality of Life in German Patients with Juvenile Idiopathic Arthritis in Comparison to German General Population
复制标题
DOI：
10.1371/journal.pone.0153267
复制
发表时间：
2016-04-26
期刊：
影响因子：
3.7
通讯作者：
Radon, Katja
中科院分区：
文献类型：
--
作者：
Barth, Swaantje;Haas, Johannes-Peter;Radon, Katja
本研究的目的是调查既往诊断为幼年特发性关节炎（JIA）的成年患者的健康相关生活质量（HRQOL），将其HRQOL与普通人群进行比较，并确定与不良结局相关的因素。表示“交叉”之义通过向德国风湿病中心的一个大的既往和当前患者队列邮寄问卷进行了横断面调查，儿童和青少年。仅纳入诊断符合JIA的成人患者（≥ 18岁）（n = 2592;应答率66%）。问卷包括HRQOL（EQ 5D）、疾病相关问题和社会人口统计学信息。对德国一般人群的活动、自我护理、日常活动、疼痛和焦虑/抑郁问题的患病率和95%置信区间（CI）进行标准化。使用逻辑回归模型确定了与JIA患者HRQOL低相关的因素。结果62%的研究人群为女性;年龄范围为18-73岁。在所有维度中，JIA患者报告的问题在统计学上显著多于一般人群，其中疼痛维度（JIA患者56%; 95% CI 55-58%;一般人群28%; 26-29%）和焦虑/抑郁维度（28%; 27-29% vs. 4%; 4-5%）的差异最大。较低的HRQOL在JIA患者与女性性别，年龄较大，教育水平较低，仍在风湿治疗和disability.ConclusionsHRQOL在成人JIA患者是相当低的，比一般人群。由于该队列包括既往患者，因此目前可用的新治疗方案有望在未来改善HRQOL。
ObjectiveAims of the study were to investigate health-related quality of life (HRQOL) in adult patients with former diagnosis of Juvenile Idiopathic Arthritis (JIA), to compare their HRQOL with the general population and to identify factors related to a poor outcome.MethodsIn 2012, a cross-sectional survey was performed by mailing a questionnaire to a large cohort of former and current patients of the German Centre for Rheumatology in Children and Adolescents. Only adult patients (>= 18 years) with a diagnosis compatible with JIA were included (n = 2592; response 66%). The questionnaire included information about HRQOL (EQ5D), disease-related questions and socio-demographics. Prevalence and 95% confidence intervals (CI) of problems with mobility, self-care, usual activities, pain and anxiety/depression were standardized to the German general population. Factors associated with low HRQOL in JIA patients were identified using logistic regression models.ResultsSixty-two percent of the study population was female; age range was 18-73 years. In all dimensions, JIA patients reported statistically significantly more problems than the general population with largest differences in the pain dimension (JIA patients 56%; 95% CI 55-58%; general population 28%; 26-29%) and the anxiety/ depression dimension (28%; 27-29% vs. 4%; 4-5%). Lower HRQOL in JIA patients was associated with female sex, older age, lower level of education, still being under rheumatic treatment and disability.ConclusionsHRQOL in adult JIA patients is considerably lower than in the general population. As this cohort includes historic patients the new therapeutic schemes available today are expected to improve HRQOL in future.