Path integration selectively predicts midlife risk of Alzheimer's disease.
Path integration selectively predicts midlife risk of Alzheimer's disease.
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路径整合选择性地预测中年阿尔茨海默病的风险。
DOI：
10.1101/2023.01.31.526473
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Ritchie,CraigW
中科院分区：
文献类型：
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作者：
Newton,Coco;Pope,Marianna;Rua,Catarina;Henson,Richard;Ji,Zilong;Burgess,Neil;Rodgers,ChristopherT;Stangl,Matthias;Dounavi,Maria-Eleni;Castegnaro,Andrea;Koychev,Ivan;Malhotra,Paresh;Wolbers,Thomas;Ritchie,Karen;Ritchie,CraigW
内嗅皮质（EC）是阿尔茨海默病（AD）中第一个表现出神经退行性变的皮质区域，与EC网格细胞功能障碍相关。考虑到网格细胞在路径整合中的作用，我们预测路径整合障碍将代表阿尔茨海默病风险成人的第一个行为改变。利用沉浸式虚拟现实技术，我们发现中年路径整合障碍预示着遗传性和生理性AD风险，而在情景记忆或其他空间行为测试中没有相应的损伤。损伤与较差的角度估计有关，并与后内侧EC的六向网格状fMRI信号有关。这些结果表明，路径整合的改变可能代表了AD从危险状态到疾病发作的过渡点，在其他认知领域受损之前。
The entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer’s disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration, we predicted that path integration impairment would represent the first behavioural change in adults at-risk of AD. Using immersive virtual reality, we found that midlife path integration impairments predicted both hereditary and physiological AD risk, with no corresponding impairment on tests of episodic memory or other spatial behaviours. Impairments related to poorer angular estimation and were associated with hexadirectional grid-like fMRI signal in the posterior-medial EC. These results indicate that altered path integration may represent the transition point from at-risk state to disease onset in AD, prior to impairment in other cognitive domains.