The radiosensitivity of the human oocyte
The radiosensitivity of the human oocyte
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DOI：
10.1093/humrep/deg016
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发表时间：
2003-01-01
影响因子：
6.1
通讯作者：
Kelsey, TW
中科院分区：
文献类型：
--
作者：
Wallace, WHB;Thomson, AB;Kelsey, TW
背景：我们确定了健康女性卵泡自然下降的最佳模型，并用该模型计算了人类卵母细胞的辐射敏感性。方法：卵巢功能衰竭患者6例，平均年龄13.2岁(12.5~16.0岁)，11.5岁(4.9~15.1岁)接受全身照射14.4Gy.我们之前估计破坏50%的卵母细胞所需的辐射剂量(LD50)为
BACKGROUND: We determined the best model available for natural follicle decline in healthy women and used this to calculate the radiosensitivity of the human oocyte. METHODS: Ovarian failure was diagnosed in six patients with a median age of 13.2 years (range 12.5-16.0) who were treated with total body irradiation (14.4 Gy) at 11.5 years of age (4.9-15.1). We previously estimated the dose of radiation required to destroy 50% of the oocytes (LD50) to be