Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.
Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.
复制标题
西班牙药草水提取物抑制核因子 kappaB 激活和环氧合酶 2 表达。
DOI：
10.1089/jmf.2009.1128
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发表时间：
2010
影响因子：
2.4
通讯作者：
VanderJagt,DorothyJ
中科院分区：
文献类型：
--
作者：
Orlando,RobertA;Gonzales,AmandaM;Hunsaker,LucyA;Franco,CarolinaR;Royer,RobertE;VanderJagt,DavidL;VanderJagt,DorothyJ
非甾体抗炎药（NSAIDs）是治疗慢性炎症成分疾病的主要选择。不幸的是，长期的非甾体抗炎药治疗经常伴有严重的副作用，包括心血管和胃肠道并发症。因此，迫切需要确定新的和更安全的治疗慢性炎症的方法来避免这些副作用。许多文化都成功地用天然草药治疗炎症性疾病。为了更好地了解天然草药治疗慢性炎症的潜力，并确定其作用机制，我们评估了西班牙文化中常用的20种草药的抗炎活性。我们建立了一种标准化的方法，从选定的草药中制备水提取物（茶），并筛选抑制肿瘤坏死因子-α-诱导的核因子κB （NF-κB）的激活，这是炎症反应的中心信号通路。许多草药茶被鉴定出具有显著的抗炎活性。特别是，通常被称为月桂的草药茶被发现是培养的小鼠巨噬细胞中NF-κ b依赖性环氧化酶-2基因表达和前列腺素e2产生的特别有效的抑制剂。这些发现表明，月桂茶提取物含有有效的抗炎化合物，通过抑制主要的信号转导途径负责诱导炎症事件。基于这些结果，月桂可能代表一种新的、安全的治疗慢性炎症的药物。
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a primary choice of therapy for diseases with a chronic inflammatory component. Unfortunately, long-term NSAID therapy is often accompanied by severe side effects, including cardiovascular and gastrointestinal complications. Because of this, there is critical need for identification of new and safer treatments for chronic inflammation to circumvent these side effects. Inflammatory diseases have been successfully remedied with natural herbs by many cultures. To better understand the potential of natural herbs in treating chronic inflammation and to identify their mechanism of action, we have evaluated the anti-inflammatory activities of 20 medicinal herbs commonly used in the Hispanic culture. We have established a standardized method for preparing aqueous extracts (teas) from the selected medicinal herbs and screened for inhibition of tumor necrosis factor-α-induced activation of nuclear factor κB (NF-κB), which is the central signaling pathway of the inflammatory response. A number of herbal teas were identified that exhibited significant anti-inflammatory activity. In particular, tea from the herb commonly called laurel was found to be an especially potent inhibitor of NF-κB-dependent cyclooxygenase-2 gene expression and prostaglandin E2production in cultured murine macrophages. These findings indicate that laurel tea extract contains potent anti-inflammatory compounds that function by inhibiting the major signal transduction pathway responsible for inducing an inflammatory event. Based on these results, laurel may represent a new, safe therapeutic agent for managing chronic inflammation.