Sex and Disease-Related Alterations of Anterior Insula Functional Connectivity in Chronic Abdominal Pain
Sex and Disease-Related Alterations of Anterior Insula Functional Connectivity in Chronic Abdominal Pain
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DOI：
10.1523/jneurosci.1683-14.2014
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发表时间：
2014-10-22
影响因子：
5.3
通讯作者：
Mayer, Emeran A.
中科院分区：
文献类型：
--
作者：
Hong, Jui-Yang;Kilpatrick, Lisa A.;Mayer, Emeran A.
静息态功能磁共振成像已被用于研究健康受试者和慢性疼痛患者的内在脑连接。人类大脑皮层（INS）内频率功率分布的性别相关差异已被报道，INS是一个涉及内感受、情感和认知影响整合的大脑区域。在这里，我们的目的是测试性别和疾病相关的改变的内在功能连接的背侧前INS。前INS从事目标导向的任务，并调制默认模式和执行控制网络。通过比较年龄匹配的女性和男性健康受试者以及肠易激综合征（IBS）（一种常见的慢性腹痛疾病）患者的背侧前INS的功能连接，我们显示了该区域功能连接的性别和疾病相关改变的证据：（一）与女性患者相比，男性患者双侧背侧前INS与内侧前额叶皮质的阳性连接增加（（2）与男性患者相比，女性患者左侧背前INS与左侧楔前叶的负连接更强，（3）女性患者双侧背前INS与背内侧PFC之间的连接存在疾病相关性差异;（4）男性IBS患者的临床特征与岛叶与背内侧PFC的连接密切相关，女性IBS患者的临床特征与岛叶与楔前叶的连接密切相关。这些发现与INS在调节静息脑中主要网络的内在功能连接方面发挥重要作用一致，并表明这种作用受性别和诊断的影响。
Resting-state functional magnetic resonance imaging has been used to investigate intrinsic brain connectivity in healthy subjects and patients with chronic pain. Sex-related differences in the frequency power distribution within the human insula (INS), a brain region involved in the integration of interoceptive, affective, and cognitive influences, have been reported. Here we aimed to test sex and disease-related alterations in the intrinsic functional connectivity of the dorsal anterior INS. The anterior INS is engaged during goal-directed tasks and modulates the default mode and executive control networks. By comparing functional connectivity of the dorsal anterior INS in age-matched female and male healthy subjects and patients with irritable bowel syndrome (IBS), a common chronic abdominal pain condition, we show evidence for sex and disease-related alterations in the functional connectivity of this region: (1) male patients compared with female patients had increased positive connectivity of the dorsal anterior INS bilaterally with the medial prefrontal cortex (PFC) and dorsal posterior INS; (2) female patients compared with male patients had greater negative connectivity of the left dorsal anterior INS with the left precuneus; (3) disease-related differences in the connectivity between the bilateral dorsal anterior INS and the dorsal medial PFC were observed in female subjects; and (4) clinical characteristics were significantly correlated to the insular connectivity with the dorsal medial PFC in male IBS subjects and with the precuneus in female IBS subjects. These findings are consistent with the INS playing an important role in modulating the intrinsic functional connectivity of major networks in the resting brain and show that this role is influenced by sex and diagnosis.