HLA class II polymorphism: Protective or risk factors to breast cancer in Tunisia?
HLA class II polymorphism: Protective or risk factors to breast cancer in Tunisia?
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DOI：
10.1007/bf02893448
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Elgaaied, Amel Ben Ammar
中科院分区：
文献类型：
--
作者：
Harrath, Amal Baccar;Loueslati, Besma Yacoubi;Elgaaied, Amel Ben Ammar
HLA system plays a key role in the tumor cells' escape from immune surveillance. Herein is the first report on the correlation of the susceptibility to breast cancer with HLA class II markers in Tunisia. Molecular typing of HLA-DRB1 and -DQB1 loci was undertaken for 70 Tunisian female patients. Comparison of allele and haplotype distribution between patients and 70 female control subjects reveals a negative association between HLA-DRB1*07-DQB1*02 and the incidence of breast cancer in the Tunisian population.
