Obesity and height in urban Nigerian women with breast cancer
Obesity and height in urban Nigerian women with breast cancer
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DOI：
10.1016/s1047-2797(02)00426-x
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发表时间：
2003-07-01
影响因子：
5.6
通讯作者：
Olopade, OI
中科院分区：
文献类型：
--
作者：
Adebamowo, CA;Ogundiran, TO;Olopade, OI
目的：探讨肥胖、身高和乳腺癌之间的关系。方法：1998年3月至2000年8月，我们对尼日利亚西南部城市的234名住院乳腺癌患者和273名人群对照进行了病例对照研究。结果：本研究没有发现肥胖(BMI大于或等于30)与乳腺癌之间的显著关联(OR=1.51，95%CI 0.87-2.62)。多因素Logistic回归分析显示，身高增加与绝经前、绝经前、绝经后乳腺癌发病风险呈正相关(OR分别为1.05、1.01、1.10、1.07、1.01、1.13)。年龄、月经周期不规律和发病年龄早也与乳腺癌风险显著相关。结论：这项研究未能证明乳腺癌风险与肥胖之间的关联，而表明在尼日利亚城市化妇女中身高与乳腺癌风险呈正相关。安·埃皮德莫尔2003；13：455-461。(C)2003 Elsevier Inc.保留所有权利。
PURPOSE: To examine the relationship between obesity, height, and breast cancer in an urban Nigerian population.METHODS: Between March 1998 and August 2000, we conducted a case-control study of hospital-based breast cancer patients (n = 234) and population-based controls (n = 273) using nurse interviewers in urban Southwestern Nigeria.RESULTS: The study did not find a significant association between obesity (BMI greater than or equal to 30) and breast cancer among all women (OR = 1.51, 95% CI 0.87-2.62) pre- (OR = 1.21, 95% CI = 0.56-2.60) and post-menopausal breast cancer patients (OR 1.82, 95% CI = 0.78-4.31) in multivariate logistic regression analysis, while increasing height was positively associated with the risk of breast cancer among all women (OR 1.05, 1.01 - 1.08), pre- (1.06, 1.01-1.10) and post-menopausal women (1.07, 1.01-1.13) for each cm. Age, irregular period, and early age of onset of periods were also found to be significantly associated with breast cancer risk.CONCLUSION: This study failed to demonstrate an association between breast cancer risk and obesity while showing that height is positively associated with risk of breast cancer in urbanized Nigerian women. Ann Epidermol 2003;13:455-461. (C) 2003 Elsevier Inc. All rights reserved.