Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer disease.
Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer disease.
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DOI：
10.1097/wad.0b013e31819cb8a2
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发表时间：
2009-07
影响因子：
2.1
通讯作者：
Burns JM
中科院分区：
文献类型：
--
作者：
Honea RA;Thomas GP;Harsha A;Anderson HS;Donnelly JE;Brooks WM;Burns JM
运动和心肺（CR）健身可能会缓和非痴呆老年人（ND）与年龄相关的区域性脑变化。健康与阿尔茨海默病（AD）相关的大脑变化的关系尚未得到充分研究，特别是在早期AD中不成比例地受到影响的海马体中。载脂蛋白E4（apoE 4）基因型在调节这种关系中的作用也是未知的。65岁以上的非痴呆（n=56）和早期AD受试者（n=61）进行MRI和CR健康评估。采用基于体素的形态测定（VBM）技术来识别AD相关萎缩。我们分析了CR适应性与组内白色和灰质的关系，评估了受AD相关萎缩影响最大的区域中与适应性相关的脑体积变化，然后分析了apoE 4携带者之间的差异适应性-脑关系。轻度AD患者的颞叶内侧、颞叶和顶叶皮质存在萎缩。在AD患者中，CR适应度与顶叶和内侧颞叶体积呈显著正相关。在全局或SVC分析中，ND受试者的脑容量与CR适应性之间没有显著关系。两组间体适能× apoE 4基因型无显著交互作用。在早期AD中，心肺适应性与内侧颞叶和顶叶皮质中的区域脑体积相关，这表明维持心肺适应性可能会改变AD相关的脑萎缩。
Exercise and cardiorespiratory (CR) fitness may moderate age-related regional brain changes in nondemented older adults (ND). The relationship of fitness to Alzheimer's disease (AD) related brain change is understudied, particularly in the hippocampus which is disproportionately affected in early AD. The role of apolipoprotein E4 (apoE4) genotype in modulating this relationship is also unknown. Nondemented (n=56) and early-stage AD subjects (n=61) over age 65 had MRI and CR fitness assessments. Voxel-based morphometry (VBM) techniques were utilized to identify AD-related atrophy. We analyzed the relationship of CR fitness with white and gray matter within groups, assessed fitness-related brain volume change in areas most affected by AD-related atrophy, and then analyzed differential fitness-brain relationships between apoE4 carriers. Atrophy was present in the medial temporal, temporal, and parietal cortices in subjects with mild AD. There was a significant positive correlation of CR fitness with parietal and medial temporal volume in AD subjects. ND subjects did not have a significant relationship between brain volume and CR fitness in the global or SVC analyses. There was not a significant interaction for fitness × apoE4 genotype in either group. In early-stage AD, cardiorespiratory fitness is associated with regional brain volumes in the medial temporal and parietal cortices suggesting that maintaining cardiorespiratory fitness may modify AD-related brain atrophy.