The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection
The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection
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DOI：
10.1212/01.wnl.0000208411.01172.0b
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发表时间：
2006-04-25
期刊：
影响因子：
9.9
通讯作者：
Lichy, C
中科院分区：
文献类型：
--
作者：
Longoni, M;Grond-Ginsbach, C;Lichy, C
自发性颈动脉夹层(SCAD)的发病机制尚不清楚，但近期感染可能是SCAD的触发因素。(1，2)动脉夹层后急性期血浆高敏C反应蛋白(HsCRP)水平升高进一步提示炎症机制的参与。(3)在最近对年轻中风患者进行的一项关于潜在危险基因多态性的研究中，我们重点关注了Pola等人之前描述的细胞间黏附分子1(ICAM-1或CD54)的E469K多态性。(4)在受脑缺血影响的意大利老年人群中，这是中风的危险因素。因为我们发现E469K多态与卒中SCAD患者亚组之间存在显著的相关性(未发表的数据)，所以我们随后分析了第二个和更大系列的SCAD患者的ICAM-1 E469K多态，以证实这一发现。
The mechanisms involved in the pathogenesis of spontaneous cervical arterial dissection (sCAD) are unclear, but recent infection may be a triggering factor in sCAD. (1,2) Increased plasma levels of high-sensitivity C-reactive protein (hsCRP) in the postacute phase after arterial dissection further suggests an involvement of inflammatory mechanisms. (3) In a recent study in young stroke patients regarding polymorphisms of potentially risk-bearing genes, we focused on the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1 or CD54) previously described by Pola et al. (4) as a risk factor for stroke in an elderly Italian population affected by cerebral ischemia. Because we found a significant association between the E469K polymorphism and the subgroup of stroke patients with sCAD ( unpublished data), we then analyzed the ICAM-1 E469K polymorphism in a second and larger series of sCAD patients in order to confirm this finding.