Role of estradiol in puerperal psychosis
Role of estradiol in puerperal psychosis
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DOI：
10.1007/s002130051149
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发表时间：
1999-11-01
影响因子：
3.4
通讯作者：
Aito, M
中科院分区：
文献类型：
--
作者：
Ahokas, A;Aito, M
基本原理：产后期被认为是发生精神疾病的风险增加的时期，具有长期的不良后果。精神病是这些疾病中最严重的，可能对精神病药物有抗药性。目的：我们提出了两个妇女与产后精神病谁有低血清雌二醇，难治性精神病药物治疗，但成功地回应雌二醇治疗。方法：在基线和舌下含服17-β雌二醇治疗期间测定血清雌二醇浓度。采用简明精神病评定量表评定疗效。结果：两例患者治疗前雌二醇浓度均较低（28和54 pmol/l）。在雌二醇治疗期间，血清雌二醇的上升与精神病症状的下降相一致。雌二醇治疗的中断导致了反弹的华丽的精神病症状在这两个案件。结论：雌二醇可能与产后精神病有因果关系，并在治疗这种疾病方面具有重要意义。
Rationale: Postpartum period has been considered a time of increased risk for the development of psychiatric disorders with long-lasting adverse consequences. Psychoses are the most severe of these illnesses and can be resistant to psychiatric medication. Objective: We present two women with puerperal psychosis who had low serum estradiol, were refractory to neuroleptic medication but responded successfully to estradiol treatment. Methods: Serum estradiol concentration was measured at baseline and during the treatment with sublingual 17-beta estradiol. Treatment effect was evaluated using Brief Psychiatric Rating Scale. Results: Both patients had a low pretreatment estradiol concentration (28 and 54 pmol/l). During treatment with estradiol, the rise in serum estradiol coincided with a decline of psychotic symptoms. Discontinuation of estradiol treatment resulted in a rebound of florid psychotic symptoms in both cases. Conclusions: Estradiol may have a causal relation to postpartum psychosis and significance in the treatment of this illness.