Genetic oscillators in development
Genetic oscillators in development
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DOI：
10.1111/dgd.12262
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发表时间：
2016-01
期刊：
影响因子：
4.6
通讯作者：
Koichiro Uriu
中科院分区：
文献类型：
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作者：
Koichiro Uriu
在发育过程中，形态发生过程在时间上是严格协调的。发育中的组织细胞需要保持时间的机制。其中一种计时机制是利用基因表达的振荡。振荡基因表达可以由转录/翻译反馈回路产生，通常被称为基因振荡器。在这篇综述文章中，我们讨论了遗传振荡在细胞分裂、细胞运动和细胞分化等发育过程中的作用。我们首先介绍产生基因表达节奏的基因调控网络。然后讨论发育过程如何影响遗传振荡子。例子包括脊椎动物体细胞发生和神经祖细胞分化，以及用于比较的生物钟。为了理解遗传振荡子在发育过程中的行为，有必要同时考虑基因表达动力学和细胞行为。理论建模结合单细胞分辨率的实时成像将是分析发育过程中遗传振荡的有力工具。
In development, morphogenetic processes are strictly coordinated in time. Cells in a developing tissue would need mechanisms for time‐keeping. One such time‐keeping mechanism is to use oscillations of gene expression. Oscillatory gene expression can be generated by transcriptional/translational feedback loops, usually referred to as a genetic oscillator. In this review article, we discuss genetic oscillators in the presence of developmental processes such as cell division, cell movement and cell differentiation. We first introduce the gene regulatory network for generating a rhythm of gene expression. We then discuss how developmental processes influence genetic oscillators. Examples include vertebrate somitogenesis and neural progenitor cell differentiation, as well as the circadian clock for comparison. To understand the behaviors of genetic oscillators in development, it is necessary to consider both gene expression dynamics and cellular behaviors simultaneously. Theoretical modeling combined with live imaging at single‐cell resolution will be a powerful tool to analyze genetic oscillators in development.