Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region.
Three type 6 hepatitis C virus subgroups among blood donors in the Yangon area of Myanmar are identified as subtypes 6m and 6n, and a novel subtype by sequence analysis of the core region.
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DOI：
10.18926/amo/30719
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发表时间：
2006-12
影响因子：
0.5
通讯作者：
Toshiyuki Shinji;A. Lwin;Katsunori Gokan;Mikako Obika;Hiromasa Ryuko;M. Khin;S. Okada;N. Koide
中科院分区：
文献类型：
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作者：
Toshiyuki Shinji;A. Lwin;Katsunori Gokan;Mikako Obika;Hiromasa Ryuko;M. Khin;S. Okada;N. Koide
此前，通过对NS5B序列的系统发育分析，我们发现缅甸存在三个6型变异亚群(M6-1、M6-2和M6-3)。根据丙型肝炎的新命名，M6-1和M6-2分别属于6m和6n亚型，但M6-3未被归类。在本研究中，我们对这些6型变异亚群的核心区进行了测序和系统发育分析。被NS5B序列命名为6m或6n的血清标本经核心区分析也被鉴定为6m或6n。根据其核心区分析，M6-3(样本名称Myan-3e-3)仍未被分配到一个亚组。这项研究的结果表明，无论是核心区还是NS5B区都可以分析丙型肝炎病毒的亚型。
Previously, using phylogenetic analysis of NS5b sequences, we found that three type 6 variant subgroups (M6-1, M6-2 and M6-3) exist in Myanmar. According to the new nomenclature of hepatitis C, M6-1 and M6-2 belong to subtypes 6m and 6n, respectively, but M6-3 is unassigned. In this study, we sequenced and phylogenetically analyzed the core region of these type 6 variant subgroups. Serum samples assigned as 6m or 6n by NS5b sequence were also identified as 6 m or 6n by core region analysis. The M6-3 (sample name MYAN-3E-3) remained unassigned to a subgroup based on its core region analysis. The findings of this study suggest that either the core region or the NS5b region can be analyzed for HCV subtype classification.