Colorectal cancer classification based on gene expression is not associated with FOLFIRI response.
Colorectal cancer classification based on gene expression is not associated with FOLFIRI response.
复制标题
基于基因表达的结直肠癌分类与 FOLFIRI 反应无关。
DOI：
10.1038/nm.3701
复制
发表时间：
2014
期刊：
影响因子：
82.9
通讯作者：
Hidalgo,Manuel
中科院分区：
文献类型：
--
作者：
Martinez-Garcia,Raquel;Lopez-Casas,PedroP;Rico,Daniel;Valencia,Alfonso;Hidalgo,Manuel
We recently reported a colorectal cancer (CRC) subtype transcriptional classifier that defined five subtypes using published transcriptional profile data sets, and we suggested an association between certain subtypes, including the ‘stem-like’subtype, and response to first-line FOLFIRI treatment1. These associations were based on analysis of transcription profiles from a published study2 (referred to as the Del Rio data set) of 21 first-line FOLFIRI-treated patients and on analysis of the responses of eight CRC cell lines to treatment in vitro with a combination of irinotecan and 5-fluorouracil (key components of the FOLFIRI treatment protocol).Martinez-Garcia et al. 3 take issue with the reported association between subtype and FOLFIRI response, noting that the association we reported was not statistically significant (P= 0.18) and was not corroborated by their analysis of ten additional patients. They conclude that “it is likely that to obtain an association between a subtype and response to treatment, a larger data set is needed.” We agree with that assessment. Indeed, it was the small sample size and the not quite significant association of the stem-like subtype with FOLFIRI response that prompted us to assess response to FOLFIRI components in vitro using CRC cell lines. Our suggestion of a possible association between stem-like subtype and FOLFIRI response was based on the combination of clinical and biological response associations. As such, what we presented was a preliminary association
