Rheumatoid arthritis lung disease - Determinants of radiographic and physiologic abnormalities
Rheumatoid arthritis lung disease - Determinants of radiographic and physiologic abnormalities
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DOI：
10.1002/art.1780391014
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发表时间：
1996-10-01
影响因子：
--
通讯作者：
Schwartz, DA
中科院分区：
文献类型：
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作者：
Saag, KG;Kolluri, S;Schwartz, DA
目标。目的探讨类风湿性关节炎间质性肺病(RA-ILD)的放射学和生理学异常的患病率及重要的临床预测指标。确定了一组未选定的确诊为类风湿性关节炎和已知肺部疾病的患者(n=336)，并对类风湿性关节炎的疾病活动性和严重性进行了评估。结果包括由用力肺活量(FVC)和一氧化碳弥散量(DLCO)的肺功能测试确定的异常，和/或间质浸润性胸片所见。我们使用多变量统计模型来确定吸烟和其他RA特异性因素对感兴趣的肺部异常的独立意义。在32.4%的患者中，肺部检查至少发现了3个异常发现中的一个。这些异常发现包括FVC
Objective. To determine the prevalence and important clinical predictors of radiographic and physiologic abnormalities indicative of rheumatoid arthritis interstitial lung disease (RA-ILD).Methods. An unselected cohort of patients with a confirmed diagnosis of RA and known lung disease were identified (n = 336) and evaluated for RA disease activity and severity. Outcomes included abnormalities determined by the pulmonary function tests of forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLco), and/or chest radiographic findings of interstitial infiltrates. We used multivariable statistical modeling to determine the independent significance of cigarette smoking and other RA-specific factors on the pulmonary abnormalities of interest.Results. At least 1 of the 3 abnormal findings was identified by pulmonary tests in 32.4% of all patients. These abnormal findings included an FVC