Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes
Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes
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DOI：
10.1016/j.neulet.2005.12.085
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发表时间：
2006-05-08
影响因子：
2.5
通讯作者：
Kapczinski, Flavio
中科院分区：
文献类型：
--
作者：
Cunha, Angelo B. M.;Frey, Benicio N.;Kapczinski, Flavio
遗传学和药理学研究表明，脑源性神经营养因子（BDNF）可能与双相情感障碍（BD）的病理生理学相关。本研究采用酶联免疫吸附试验（ELISA）检测了躁狂、抑郁、心境正常的BD患者和匹配的健康对照者的血清BDNF水平。与正常胸腺患者和对照组相比，躁狂（p = 0.019）和抑郁（p = 0.027）BD患者血清BDNF水平降低。血清BDNF水平与躁狂（r =-0.37，p = 0.005）和抑郁（r =-0.30，p = 0.033）症状的严重程度呈负相关。这些发现进一步支持了BDNF信号系统可能在BD的病理生理学中发挥作用的假设。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Genetic and pharmacological studies have suggested that brain-derived neurotrophic factor (BDNF) may be associated with the pathophysiology of bipolar disorder (BD). The present study investigated serum BDNF levels in manic, depressed, euthymic BD patients and in matched healthy controls, using an enzyme-linked immunosorbent assay (sandwich-ELISA). Serum BDNF levels were decreased in manic (p = 0.019) and depressed (p = 0.027) BD patients, as compared with euthymic patients and controls. Serum BDNF levels were negatively correlated with the severity of manic (r = -0.37, p = 0.005) and depressive (r = -0.30, p = 0.033) symptoms. These findings further support the hypothesis that the BDNF signaling system may play a role in the pathophysiology of BD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.