Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues.
Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues.
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DOI：
10.12688/f1000research.19441.1
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Goormaghtigh, Frederic
中科院分区：
文献类型：
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作者：
Bumann, Dirk;Fanous, Joseph;Goormaghtigh, Frederic
抗生素化疗能有效治愈许多由易感细菌病原体引起的感染。然而，在某些情况下，即使延长治疗时间也不能完全根除宿主组织中的致病菌。一个常见的潜在机制模型假设细菌持久性的随机形成类似于在实验室培养中观察到的。然而，与受感染宿主组织的复杂性相关的其他解释也可能相关。我们讨论了其中的几个方面，并强调需要综合分析作为新的控制策略的基础。
Antibiotic chemotherapy effectively cures many infections caused by susceptible bacterial pathogens. However, in some cases, even extended treatment duration does not completely eradicate the pathogenic bacteria from host tissues. A common model for underlying mechanisms assumes the stochastic formation of bacterial persisters similar to observations in laboratory cultures. However, alternative explanations related to the complexity of infected host tissues could also be relevant. We discuss several of these aspects and emphasize the need for integrated analysis as a basis for new control strategies.