Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.
Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats.
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DOI：
10.1021/nl0484752
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发表时间：
2005
期刊：
影响因子：
10.8
通讯作者：
A. Yokoyama;Y. Sato;Y. Nodasaka;Satoru Yamamoto;T. Kawasaki;M. Shindoh;T. Kohgo;T. Akasaka;M. Uo;F. Watari;K. Tohji
中科院分区：
文献类型：
--
作者：
A. Yokoyama;Y. Sato;Y. Nodasaka;Satoru Yamamoto;T. Kawasaki;M. Shindoh;T. Kohgo;T. Akasaka;M. Uo;F. Watari;K. Tohji
评价了对帽堆叠的碳纳米纤维（H-CNF）的组织反应。将H-CNFs植入大鼠皮下组织。组织学和超微结构的调查进行了透射电子显微镜。虽然在H-CNFs周围观察到许多巨噬细胞和异物巨细胞，但未观察到严重的炎症反应，如坏死。在吞噬细胞的溶酶体空泡中观察到一些H-CNFs。这些结果表明，H-CNFs不是强的前体物质，在体内被吞噬。
The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.