Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons
Prenatal glucocorticoid exposure affects learning and vulnerability of cholinergic neurons
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DOI：
10.1016/j.neurobiolaging.2005.11.015
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
Calza, Laura
中科院分区：
文献类型：
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作者：
Emgard, Mia;Paradisi, Michela;Calza, Laura
合成糖皮质激素的产前治疗通常用作有早产风险的妇女的治疗。然而，人们对这些治疗对胎儿的终身影响知之甚少。在本研究中，我们评估了产前糖皮质激素治疗后成年大鼠的认知功能以及胆碱能神经元对（192）IgG-皂草素免疫损伤的易感性。Morris水迷宫结果显示，产前暴露于地塞米松的成年大鼠的学习和记忆功能存在显著差异，暴露于（192）IgG-皂草素后进一步出现认知缺陷。与对照组相比，地塞米松治疗组大鼠皮层胆碱乙酰转移酶活性降低。此外，大鼠产前暴露于dexa，或beta2显示了显着降低胆碱乙酰转移酶活性相比，对照组大鼠（192）IgG-皂草素损伤后。我们报告行为和生化证据改变认知功能和增加的敏感性胆碱能神经元（192）IgG-皂草素在成年大鼠产前糖皮质激素治疗后。总之，这些结果表明，产前地塞米松治疗可能会影响认知功能，使胆碱能神经元更容易受到以后生活中的挑战。(c)2005年爱思唯尔公司All rights reserved.
Prenatal treatment with synthetic glucocorticoids is commonly used as a treatment for women at risk of preterm delivery. However, little is known about the life-long consequences of these treatments on the fetus. In the present study, we evaluated cognitive function as well as susceptibility of cholinergic neurons to (192)IgG-saporin immunolesion in adult rats after prenatal glucocorticoid treatment. Morris water maze results revealed a significant difference in learning and memory function in adult rats that were prenatally exposed to dexamethasone, and further cognitive deficits after (192)IgG-saporin exposure. Choline acetyl transferase activity was decreased in the cortex of dexamethasone-treated rats compared with controls. In addition, rats prenatally exposed to either dexa, or betamethasone revealed a dramatic decrease in choline acetyl transferase activity compared to control rats after (192)IgG-saporin lesion. We report behavioral and biochemical evidence for altered cognitive function and increased susceptibility of cholinergic neurons to (192)IgG-saporin in adult rats after prenatal glucocorticoid treatment. Taken together, these results suggest that prenatal treatment with dexamethasone could affect cognitive functions and render cholinergic neurons more vulnerable to challenges later in life. (c) 2005 Elsevier Inc. All rights reserved.