Noise in gene expression as the source of non-genetic individuality in the chemotactic response of Escherichia coli
Noise in gene expression as the source of non-genetic individuality in the chemotactic response of Escherichia coli
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DOI：
10.1016/s0014-5793(03)00857-3
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发表时间：
2003-08-28
期刊：
影响因子：
3.5
通讯作者：
Levin, MD
中科院分区：
文献类型：
--
作者：
Levin, MD
介导细菌趋化性的信号转导途径的确定性计算机模型被用来检查在两个未受刺激的游泳行为和适应时间的细胞克隆群体的刺激的变化。该途径中蛋白质的拷贝数是从一个简化的转录和翻译模型中计算出来的，该模型预测了比泊松统计更精确的数据。模拟和实验的个性数据可以带来很好的协议上的不同的噪音强度的蛋白质拷贝数分布。在模拟中，通路中的所有蛋白质都在很大程度上参与了表型多样性的出现，尽管随着拷贝数的增加，影响力略有下降。(C)2003年由Elsevier B.V.代表欧洲生物化学学会联合会出版。
A deterministic computer model of the signal transduction pathway mediating bacterial chemotaxis was used to examine the variation in both unstimulated swimming behaviour and adaptation time to stimuli in clonal populations of cells. Copy numbers of proteins in the pathway were computed from a simplified model of transcription and translation that predicts greater-than-Poissonian statistics. Simulated and experimental individuality data could be brought into good agreement on varying the noise strength of the protein copy number distributions. In the simulations, all the proteins in the pathway are involved to a significant degree in the appearance of phenotypic diversity, although there is a modest decrease in influence with increasing copy number. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.