Accuracy in detecting prenatal drug exposure
Accuracy in detecting prenatal drug exposure
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DOI：
10.1177/002204269902900203
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发表时间：
1999-03-01
影响因子：
1.7
通讯作者：
Salvator, A
中科院分区：
文献类型：
--
作者：
Arendt, RE;Singer, LT;Salvator, A
产前可卡因影响调查所遇到的一个基本问题是有效地确定和量化接触。基于以下来源的组合：（a）病历审查（B）产妇尿液毒理学筛查，（c）胎粪分析，以及（d）415名婴儿的产妇产后访视药物暴露状态。使用此组合作为基准，发现产妇产后访视最敏感，而病历审查的准确性略低。胎粪分析和尿液筛查的漏诊率均高于访谈或记录审查方法。然而，胎粪分析和产后访谈都发现了另一个遗漏的可卡因暴露病例。在胎粪中发现的可卡因量与母体报告中的可卡因量之间的相关性表明，可卡因代谢物苯甲酰芽子碱是最好的生物标志物。量化重度暴露与轻度暴露需要结合胎粪分析和产妇产后访谈技术。
A basic problem encountered by investigations of prenatal cocaine effects has been the valid identification and quantification of exposure. Based on a combination of sources: (a) medical record review (b) maternal urine toxicology screen, (c) meconium analysis, and (d) maternal postpartum interview drug exposure status of 415 infants was established Using this combination as a benchmark, maternal postpartum interview was found most sensitive, while medical record review was slightly less accurate. Meconium analysis and urine screens both demonstrated miss rates greater than the interview or record review methods. Meconium analysis and postpartum interview however, each detected cases of cocaine exposure that the other had missed. Correlations between the amount of cocaine found in meconium and in maternal report indicated that the cocaine metabolite benzoylecgonine was the best biological marker. Quantifying heavy versus light exposure required a combination of both meconium analysis and maternal postpartum interview techniques.